Journal: International Journal of Molecular Sciences
Article Title: Prolonged QT Interval in HIV-1 Infected Humanized Mice Treated Chronically with Dolutegravir/Tenofovir Disoproxil Fumarate/Emtricitabine †
doi: 10.3390/ijms27010519
Figure Lengend Snippet: Changes in ventricular depolarization/repolarization activity of the ECG in hearts from uninfected controls (green), HIV-1-infected (red), and HIV-1-infected Hu-mice treated with DTG/TDF/FTC. Panel ( A ) shows QRS complex, Panel ( B ) shows the S wave amplitude, Panel ( C ) shows J wave amplitude and Panel ( D ) shows QTc interval. Data shown are mean ± SEM, with n = 8 mice per group, four males and four females. Black arrows indicate the start of DTG/TDF/FTC treatment. The FUJIFILM Visual Sonics offline software Vevo LAB 5.7.1 was used to obtain parameter values. * Denotes significantly different from uninfected (control), p < 0.05; # denotes significantly different from HIV-1-infected, p < 0.05.
Article Snippet: Lead II ECG signals were recorded using a Fujifilm Visual Sonics Vevo 3100 system and accompanying THM150 Physiology Monitoring System (Fujifilm Visual Sonics, Toronto, ON, Canada).
Techniques: Activity Assay, Infection, Software, Control